Lipid nanoparticles have proven their value with innovative nanomedicines already approved for market use, demonstrating their transformative potential in drug delivery. Despite these advancements, lipid nanoparticle development for clinical applications still faces numerous challenges, such as lipid component selection, the enhancement of stability and [...]
The efficacy of therapeutic agents can be profoundly influenced by the strategies employed to deliver them to their site of action. The development of advanced drug delivery platforms has the potential to revolutionize the therapeutical outcomes in every medical area, enhancing the precision and [...]
Distinguishing between different types of nanocarriers can be confusing even for those who belong to the scientific community. Between the most popular lipid nanosystems, liposomes and lipid nanoparticles are often easily mistaken. Furthermore, a basic understanding of both nanocarriers' characteristics isn’t often enough when [...]
Despite remarkable advancements in pharmaceutical research, the potential of many treatments remains unexploited due to several challenges related to their pharmacokinetic and pharmacodynamic profiles. These challenges often involve the body’s natural barriers, suboptimal drug absorption, rapid metabolism, and undesirable systemic side effects. Moreover, the [...]
Natural barriers to drug administration protect the body from foreign substances or micro-organisms while significantly impairing the distribution and therapeutic targeting of medicines to specific tissues or organs. Understanding how to bypass them is essential for addressing several drug delivery challenges faced while developing [...]
Gene therapy is a promising therapeutic approach that has experienced significant growth in recent decades, with gene nanomedicines reaching the clinics. However, translating more gene nanomedicines from bench to bedside is still challenging. The use of robust preclinical models that can better predict the [...]
Rare diseases collectively affect approximately 400 million patients worldwide [1]. Nevertheless, this number is expected to increase thanks to the rapid evolution of sequencing technologies that have identified more than 6,000 to 10,000 rare diseases [2]. However, most rare diseases still lack specific treatments, [...]
Exosomes, subcellular structures that act as specific carriers for transferring genetic material and information between cells, demonstrate the potential to become significant players in targeted drug delivery and personalized medicine. Their tumor-homing properties and ability to cross biological barriers are among the factors contributing [...]
Despite significant advancements in molecular medicine, obstacles such as low solubility and poor tissue accessibility impede the clinical translation of promising molecules and therapeutic agents. In the ever-evolving landscape of scientific research, nanotechnology emerges as a beacon of innovation, offering unique versatility to overcome [...]
The potential of non-viral lipid delivery systems for improving global health has been proven once again. From rare diseases to cancer, gene editing and gene therapies will undoubtedly benefit from the latest advances in nanomedicine. In February 2024, the results from a promising combined phase [...]
