Despite remarkable advancements in pharmaceutical research, the potential of many treatments remains unexploited due to several challenges related to their pharmacokinetic and pharmacodynamic profiles. These challenges often involve the body’s natural barriers, suboptimal drug absorption, rapid metabolism, and undesirable systemic side effects. Moreover, the [...]
Natural barriers to drug administration protect the body from foreign substances or micro-organisms while significantly impairing the distribution and therapeutic targeting of medicines to specific tissues or organs. Understanding how to bypass them is essential for addressing several drug delivery challenges faced while developing [...]
Gene therapy is a promising therapeutic approach that has experienced significant growth in recent decades, with gene nanomedicines reaching the clinics. However, translating more gene nanomedicines from bench to bedside is still challenging. The use of robust preclinical models that can better predict the [...]
Rare diseases collectively affect approximately 400 million patients worldwide [1]. Nevertheless, this number is expected to increase thanks to the rapid evolution of sequencing technologies that have identified more than 6,000 to 10,000 rare diseases [2]. However, most rare diseases still lack specific treatments, [...]
Melanoma, a type of skin cancer originating from melanocytes, has become a global health concern due to its rising incidence. It ranks as the fifth most prevalent cancer in men and the sixth most common in women [1]. To advance in the fight against this [...]
2024 is here full of new resolutions and challenges. And so, in an ever-evolving field such as medicine, it's inevitable to wonder what exciting advances the new year will bring. Nature medicine has asked leading researchers to discover what clinical trials may impact medicine in [...]
Peptide applications in biomedicine Peptides, which are short chains of amino acids, have gained significant attention in biomedicine due to their diverse applications. Their unique properties, such as high specificity, low toxicity, and excellent biocompatibility, make them valuable tools for various biomedical purposes. Here are [...]
