Despite remarkable advancements in pharmaceutical research, the potential of many treatments remains unexploited due to several challenges related to their pharmacokinetic and pharmacodynamic profiles. These challenges often involve the body’s natural barriers, suboptimal drug absorption, rapid metabolism, and undesirable systemic side effects. Moreover, the [...]
Natural barriers to drug administration protect the body from foreign substances or micro-organisms while significantly impairing the distribution and therapeutic targeting of medicines to specific tissues or organs. Understanding how to bypass them is essential for addressing several drug delivery challenges faced while developing [...]
Gene therapy is a promising therapeutic approach that has experienced significant growth in recent decades, with gene nanomedicines reaching the clinics. However, translating more gene nanomedicines from bench to bedside is still challenging. The use of robust preclinical models that can better predict the [...]
