Landing RNA2024-04-15T14:35:16+00:00

Your next go-to solution for efficient mRNA delivery

A simple and safe nanoparticle formulation for mRNA delivery

As a result of our R&D, DIVERSA offers a revolutionary breakthrough: biocompatible lipid nanoparticles that simplify your mRNA Transfection Workflows.

This easy-to-use, rapid nanoparticle formulation requires no special equipment and delivers exceptional transfection efficiency across various cell types, including immortalized and primary cells, organoids, as well as in vivo, making it simple to advance gene therapy research towards clinical applications.

Uniquely in the market, our formulation includes fluorescent labeling for cell tracking, streamlining your research workflow.

DIVERSA empowers researchers with a simple and powerful tool, transforming effective research.

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DIVERSA’s nanoparticles can be formulated in a simple way without using expensive equipment. The formulation protocol is easy to follow and simple. It minimizes material loss, ensuring maximum research value.

Efficient and Versatile

DIVERSA’s nanoparticles ensure rapid and efficient intracellular delivery of mRNA in several cell culture modles, including hard-to-transfect cells and organoids, as well as in vivo models. This versatility works for mRNA of differen molecular weigths and is suitable for a wide range of applications.

DIVERSA’S Nanoparticles are…


DIVERSA’s nanoparticles are bioinspired, ensuring safe and efficient mRNA delivery. This prioritizes cell integrity unlike traditional transfection tools such as viral vectors and harsh cationic transfection reagents.

Traceable and Customizable

DIVERSA’s nanoparticles offer traceability with an optional fluorescent tag for precise research and cell tracking. Additionally, it is possible to order customized formulations, including surface decoration with ligands of interest.

  • Suitable for in vivo and in vitro applications


  • Easy and quick formulation protocol


  • Streamlined protocol for quick application


  • Stable under physiological conditions


  • Scalable technology under GMP conditions


  • Compatible with a range of RNA sizes


  • Eco-friendly manufacturing process


  • Non-toxic and biocompatible nanoparticles

Any questions we haven’t answered?

What are nanoparticles?2024-04-03T09:55:57+00:00

Nanoparticles are particles that measure in nanometers (one billionth of a meter). They exhibit unique properties that differ from those of bulk materials, making them useful in different fields. 

How do nanoparticles work in gene delivery?2024-04-03T09:56:02+00:00

In gene delivery, nanoparticles encapsulate different types of nucleic acids, protecting them from degradation and delivering them to the cells of interest in a safe and efficient fashion.  

What are the advantages of nanoparticles over other transfection methods?2024-04-03T09:57:15+00:00

There are several methods used to deliver RNA molecules into cells: 

  • Mechanical methods, such as electroporation and sonoporation, create temporary pores in cell membranes that enable RNA entry. 
  • Chemical methods, such as lipofectamine and PEI, rely on the formation of complexes with cationic lipids or polymers that favor interactions with cell membranes and RNA entry. 
  • Viral vectors, such as adeno-associated viruses (AAV), carry RNA molecules and deliver them to target cells. 
  • Non-viral delivery systems, such as liposomes, polymeric nanoparticles, and lipid nanoparticles (LNPs), encapsulate, protect, and deliver mRNA to the target cells. The specific properties, safety, and efficacy of transfection depend on the composition of the delivery systems. Among them, LNPs are the only mRNA non-viral delivery systems that have reached the clinic. 

Mechanical and chemical methods typically harm cells and show toxicity, while they cannot be applied in an in vivo setting. Viral delivery, while effective in delivering the genetic material to the nucleus of the cells and helping integrate the DNA into the genome of the host, still poses safety concerns. In this regard, nanoparticles can definitively provide a solution towards the clinical approval of more gene therapies. 

What are the main advantages of DIVERSA’s nanoparticles?2024-04-03T14:54:49+00:00

DIVERSA’s nanoparticles are composed of a combination of biodegradable lipids, including one of the main components of cell membranes. This specific combination renders nanoparticles with excellent stability properties and a high rate of cell internalization by different cellular mechanisms. The RNA is efficiently encapsulated and protected from degradation. Additionally, biodistribution can be tailored by modifying the lipid ratios and, if needed, adding specific lipids. 

DIVERSA’s nanoparticles are simple to formulate, without the need for expensive microfluidic equipment and cartridges, and can be prepared before use. They can be acquired with a fluorescent label for cell tracking and monitoring of the cell internalization process. Their transfection properties are superior to more toxic commercial cationic reagents, and they can be used in cells, organoids, and animal models. 

DIVERSA’s nanoparticles can be customized upon request. 

What’s the difference between liposomes and DIVERSA’s nanoparticles?2024-04-03T14:56:26+00:00

Liposomes and nanoparticles are used in gene delivery, but they differ in structure and properties. 

Liposomes are spherical vesicles composed of one or more phospholipid bilayers surrounding an aqueous core. They are biocompatible and can associate with various polynucleotides, including RNA, typically upon the addition of a cationic lipid to their composition. 

In contrast, DIVERSA’s nanoparticles possess a more organized structure and incorporate key components for efficient encapsulation without relying on cationic lipids. They are designed to optimize intracellular delivery and endosomal escape while minimizing harm to cell membranes. Additionally, DIVERSA’s nanoparticles are patented, signifying a layer of innovation and facilitating clinical translation. 

DIVERSA also offers co-development services  to help you further advance your research project. 


What’s the difference between LNPs and DIVERSA’s nanoparticles?2024-04-03T14:57:32+00:00

LNPs are a type of carrier used to deliver RNA-based therapeutics, including mRNA vaccines, and have already reached clinical use. 

DIVERSA’s nanoparticles share key similarities with LNPs but boast a simpler composition.  

DIVERSA’s nanoparticles incorporate a cell membrane lipid to enhance intracellular delivery and transfection efficiency, along with a lipid for high stability. Furthermore, commercially available LNPs are offered as complex lipid mixtures requiring microfluidic equipment and cartridges for formulation. This increases formulation costs and necessitates expertise from end-users. In contrast, DIVERSA’s nanoparticles can be readily prepared using a disposable syringe following a simple and rapid protocol. 

Similar to LNPs, DIVERSA’s nanoparticles are scalable and can be formulated under GMP conditions upon request.  

Additionally, DIVERSA offers the possibility of customization for more advanced applications, such as ligand decoration and co-encapsulation of other nucleic acids or biomolecules. 

How does the cargo enter the cell?2024-04-03T09:56:11+00:00

Based on our experiments so far, we can say that DIVERSA’s Nanoparticles could internalize by a combination of active (endocytosis) and passive (fusion) routes. 

Which administration routes have been tried in vivo using this technology?2024-04-03T09:56:14+00:00

We have tested in healthy mice and models of disease, by subcutaneous, intravenous, and intraperitoneal routes. 

Can I use RNA encoding any protein?2024-04-03T09:56:17+00:00

Yes, DIVERSA mRNA DELIVERY NANOPARTICLES can be loaded with any RNA encoding for your protein of interest. We recommend using this RNA at 1mg/mL.  

Can I filter the formulation?2024-04-03T09:57:02+00:00

Yes, if necessary, DIVERSA mRNA DELIVERY NANOPARTICLES can be filtered using small 0.22 µm filters of PES membrane.  

Can I use DIVERSA mRNA DELIVERY NANOPARTICLES for in vivo studies?2024-04-03T09:53:20+00:00

Yes, DIVERSA mRNA DELIVERY NANOPARTICLES can be used in vivo. For specific recommendations and a customized and optimized prototype, contact DIVERSA.

Ensuring Safety and Biocompatibility is Our Top Priority

DIVERSA’s nanometric formulation is stable and delivers mRNA in a simple, safe, and efficient way. DIVERSA’s nanoparticles are easily formulated without the need for specialized equipment, saving costs and time.

DIVERSA’s nanoparticles are bio-inspired, ensuring optimal biocompatibility, opposite to what observed with cationic transfection reagents.

Let’s Chat!

If you have any specific questions or suggestions about the technology, we would love to hear from you! We have a dedicated technical team that is waiting for any inquiry you might have! Fill out the contact form and we will get back to you ASAP

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