Enhancing intracellular delivery of a broad range of peptides
DIVTECH Peptide Kit, based on reactive lipids, is suitable for click chemistry to conjugate any azide-modified peptide. N3-peptides will covalently react with the surface of the DIVTECH formulation by following easy and mild conditions. The modification in your peptide/s of interest is meant to facilitate its association to DIVTECH formulation and does not compromise its structure and activity.
Technical information
| Peptide delivered | pl | Peptide charge | % hydrophobic Aa |
|---|---|---|---|
3-mer |
5.9 |
-1 |
0% |
12-mer |
9.5 |
+4 |
25% |
13-mer |
9.8 |
+5 |
23% |
16-mer |
9.5 |
+7 |
50% |
19-mer |
8.6 |
+2 |
21% |
28-mer |
11.9 |
+6 |
39% |
Examples of peptides efficiently associated with DIVTECH and delivered to cells.
Reference number
DIV021
Reagent
DIVTECH Peptide Kit
Amount of reagent
2 x 1 mL
Molecules delivered
N3-modified peptides
Cell types
Adherent & suspension cells, organoids and 3D cultures
Cell culture conditions
Cell culture medium supplemented with/without serum
Number of experiments
1 mL of DIVTECH Small molecule is sufficient to perform 13 delivery experiments in 6-well plates, 68 experiments in 24-well plates and 405 experiments in 96-well plates.
In vivo models
Rodents and zebrafish
Administration route
Intravenous, subcutaneous, intraperitoneal, intra-articular, topical…
Storage
-20 ºC upon arrival, once formulated at 4 ºC
Provided with
2x DIVTECH empty vials, 4 tips for 1 mL pipette
Size of DIVTECH-PEPTIDE formulations and stability after 24 hours in storage conditions.
Colloidal stability of DIVTECH-PEPTIDE (12-mer and 19-mer peptides) formulations after 28 days in storage conditions.
Therapeutic efficiency of intracellular delivered peptides in free form or with DIVTECH, and compared to commercial competitors.
