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Enhancing intracellular delivery of small molecules

DIVTECH Small Molecule kit is suitable for hydrophilic and hydrophobic small molecules and can be used to efficiently deliver your compound/drug of interest to specific cell lines. DIVTECH prevents loaded drugs from external degradation and rapid clearance. It promotes optimal and targeted biodistribution, high intracellular absorption and low toxicity, boosting their therapeutic effect.

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Technical information
Drug MW (g/mol) log POW Mass (mg) % Loading (w/w) Molar (mM) % EE
Galunisertib
369.42
2.4
0.75
15%
2.03
>80%
Doramapimod
527.66
5.7
0.75
15%
1.42
>99%
Disulfiram
296.54
3.9
0.75
15%
2.53
>90%
Paclitaxel
853.91
2.5
0.05
1%
0.06
>80%
Etoposide
588.56
0.6
0.05
1%
0.09
>80%
Doxorubicin
543.52
1.3
1
20%
1.84
>90%
Oleuropein
540.51
-0.4
0.75
15%
1.39
>99%
Rose Bengal
973.67
8.5
1
20%
1.03
>95%

 

*MW: molecular weight, Log Pow: n-octanol/water partition coefficient, EE: encapsulation efficiency

Reference number

DIV010

Reagent

DIVTECH Small molecule kit

Amount of reagent

4 x 1 mL

Molecules delivered

Small molecules

Cell types

Adherent & suspension cells, organoids and 3D cultures

Cell culture conditions

Cell culture medium supplemented with/without serum

Number of experiments

1 mL of DIVTECH Small molecule is sufficient to perform 27 delivery experiments in 6-well plates, 134 experiments in 24-well plates and 800 experiments in 96-well plates.

In vivo models

Rodents and zebrafish

Administration route

Intravenous, subcutaneous, intraperitoneal, intra-articular, topical…

Storage

-20 ºC upon arrival, once formulated at 4 ºC

Provided with

4x DIVTECH empty vials, 8 tips for 1 mL pipette

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