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DIV010
DIV010

Enhancing intracellular delivery of small molecules

DIVERSA lipid nanoemulsions for promoting effective intracellular delivery of drugs (small molecules, APIs)

Technical information
Drug MW (g/mol) log POW Mass (mg) % Loading (w/w) Molar (mM) % EE
Galunisertib
369.42
2.4
0.75
15%
2.03
>80%
Doramapimod
527.66
5.7
0.75
15%
1.42
>99%
Disulfiram
296.54
3.9
0.75
15%
2.53
>90%
Paclitaxel
853.91
2.5
0.05
1%
0.06
>80%
Etoposide
588.56
0.6
0.05
1%
0.09
>80%
Doxorubicin
543.52
1.3
1
20%
1.84
>90%
Oleuropein
540.51
-0.4
0.75
15%
1.39
>99%
Rose Bengal
973.67
8.5
1
20%
1.03
>95%

 

*MW: molecular weight, Log Pow: n-octanol/water partition coefficient, EE: encapsulation efficiency

Reference number

DIV010

Reagent

DIVERSA Small Molecule Delivery Reagent

Amount of reagent

4 x 1 mL

Molecules delivered

Small molecules

Cell types

Adherent & suspension cells, organoids and 3D cultures

Cell culture conditions

Cell culture medium supplemented with/without serum

Number of experiments

1 mL of DIVTECH Small molecule is sufficient to perform 27 delivery experiments in 6-well plates, 134 experiments in 24-well plates and 800 experiments in 96-well plates.

In vivo models

Rodents and zebrafish

Administration route

Intravenous, subcutaneous, intraperitoneal, intra-articular, topical…

Shipping

Room temperature

Storage

-20 ºC upon arrival, once formulated at 4 ºC

Provided with

4x DIVTECH empty vials, 8 tips for 1 mL pipette

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